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MALT1-MI-2 (MI-2) was intraperitoneally (IP) dosed to mice at 25 mg/kg once per day for 14 days in TMD8 and HBL-1 ABC-DLBCL xenografts
10b-trihydroxy-3
1883545-53-6 (2HCl)
demonstrates robust in vivo efficacy in multiple models
represents a novel agent for ALK positive anaplastic large cell lymphoma
1, 4-DPCA - Prolyl 4-hydroxylase (P4H) Inhibitor. CAS# 331830-20-7 Catalog No.:M60288-10S MALT1-MI-2 (MI-2) was intraperitoneally (IP)1, 4 DPCA, CAS No. 331830 20 7, is a selective and cell permeable prolyl 4 hydroxylase (P4H) inhibitor. It inhibits prolyl4 hydroxylase, an oxygen sensing enzyme that targets the pro angiogenic factor HIF 1 for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis. Product information CAS
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